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英国利兹大学2022年招聘博士后（转化免疫学）

Research Fellow In Translational Immunology

University Of Leeds

Description

Research Fellow in Translational Immunology

Are you an early career researcher looking for your first challenge? Do you have a background in spondyloarthropathies and experience in entheseal model? Do you want to further your career in one of the UK's leading research intensive Universities?

The seronegative spondyloarthropathies (SpA) include psoriatic arthritis (PsA), and ankylosing spondylitis (AS), Crohn's Disease and ulcerative colitis related arthropathy. These diseases are associated with inflammation of enthesis in both the peripheral (commonly associated with PsA) or axial skeleton (commonly associated with Axial SpA and AS). Evidence from clinical trials showed that blockade of either TNF or IL-17 axis cytokines is effective in AS and PsA but IL-23 blockade failed in AS.

IL-23 blockade failure in the spine in AS has been the subject of intense scientific debate and the IL-23/17 cytokine axis at the enthesis needs elucidation. At the spinal entheses, our group has confirmed a population of gamma delta-T-cells that do not express the IL-23 receptor, but can produce IL-17A. Despite this strong adaptive immune driven disease there has been very little focus on adaptive immune cell population production of IL-17A independent of IL-23.

We have reported that the normal human spinal enthesis has a population of tissue resident memory T-cells including CD4+ and CD8+ T-cells. The CD4+ population are capable of producing IL-17A protein and appears to be independent of IL-23 (Watad A et al ARD 2020). A clear population of CD8+ T-cells that had inducible TNF, but not IL-17A was also evident at the normal enthesis (Watad A et al ARD). The objective of this research is to define IL-23 immunobiology at peripheral and axial entheses towards refining disease therapy.

To explore the post further or for any queries you may have, please contact:

Professor Dennis McGonagle

Tel: +44 (0)113 3924747

Email: D.G.McGonagle@leeds.ac.uk

The University of Leeds is committed to providing equal opportunities for all and offers a range of family friendly policies . The School of Medicine holds a Gold Athena Swan award. We are committed to being an inclusive Medical School that values all staff, and we are happy to consider job share applications and requests for flexible working arrangements from our employees.

As an international research-intensive university, we welcome students and staff from all walks of life and from across the world. We foster an inclusive environment where all can flourish and prosper, and we are proud of our strong commitment to student education. Within the Faculty/School of «Name» we are dedicated to diversifying our community and we welcome the unique contributions that individuals can bring, and particularly encourage applications from, but not limited to Black, Asian, people who belong to a minority ethnic community, people who identify as LGBT+; and people with disabilities. Candidates will always be selected based on merit and ability.

Location: Leeds - Chapel Allerton Hospital

Faculty/Service: Faculty of Medicine & Health School/Institute: Leeds Institute of Rheumatic & Musculoskeletal Medicine (LIRMM) Category: Research Grade: Grade 7 Salary: £34,304 to £40,927 p.a. Post Type: Full Time Contract Type: Fixed Term (Available until 30th June 2024 due to external grant income) Release Date: Friday 11 March 2022 Closing Date: Thursday 31 March 2022 Reference: MHLRM1179 Downloads: Candidate Brief

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