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Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Summary:

Reporting to Scientist, Immuno-oncology, the candidate will work with the Immuno-oncology team by contributing to the development and execution of immune cell assays to evaluate novel oncology drug candidates. The successful candidate will have solid technical experience and enthusiasm for working in a team environment to develop new anticancer drugs.

Responsibilities:

- Actively participate, under supervisor’s direction, in the execution of immune cell assays for drug candidate evaluation, mechanistic studies, and biomarker development

- Assist in performing cell biology, molecular biology, and biochemical techniques including primary and tumor cell culture, lymphocyte activation and cytotoxicity assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, immunoprecipitation, and western blotting

- Perform a wide range of assigned research experiments with efficiency, accuracy and attention to detail, conduct analysis and report results

- Follow protocols and function with limited supervision

- Contribute to design of experimental procedures and read and understand technical literature

- Interact with manager and project team to review data and plan next steps

- Record experimental details and maintain laboratory notebook

- Cultivate positive and productive working relationships with colleagues

- Prepare and present work at group meetings

- Participate in maintenance of routine laboratory instrumentation and supplies

- Use instrumentation to perform basic experiments

- Be flexible to changing priorities

- Respect laboratory safety policies and practices

Specific Duties:

- Execute, under supervisor’s direction, in-vitro immunologic assays for evaluating activity and mechanism of action of Immuno-oncology drug candidates using key immune cell populations

- Assist in developing in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials

- Generate, analyze, and report experimental results

- Participate in Immuno-oncology team meetings to present data and provide analysis

- Learn current techniques and procedures

- Contribute content to non-clinical pharmacology study reports, invention disclosures, investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate

Qualifications:

- B.S. or M.S. degree in life sciences or medical sciences field with at least 4 years (B.S.) or 2 years (M.S.) of successful experience as a research associate and at bench in an industrial setting

- Familiarity with experimental techniques and knowledge of immunology and cancer cell biology preferable

- Experience in performing primary immune cell assays using key immune cell populations: CD4+ and CD8+ T cells, Tregs, NK cells, dendritic cells, MDSCs

- Familiarity with techniques related to biomarker research and development

- Relevant skills include immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, immunocytochemistry, microscopy), and molecular biology (molecular cloning, transient and stable gene silencing, recombinant protein engineering) techniques

- Familiarity with and experience in the drug development process from discovery through IND filing in an industry setting

- Ability to multitask, independently organize time and plan specifics of work

- Excellent communication and interpersonal skills demonstrated in a team environment

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

Qualifications

Skills/Knowledge Required:

ORGANIZATIONAL/JUDGEMENT:

The incumbent must have planning skills for scheduling experimental studies to meet project team deadlines. The position requires problem solving ability and skills in resolving technical questions in a multi-disciplinary environment. The incumbent must keep abreast of current techniques within the field and the various scientific areas affecting normal and tumor cell growth.

SUPERVISION:

DIRECT and INDIRECT: None required.

ACCOUNTABITY:

The position is responsible for executing research plans in the defined area of investigation under direction of their supervisor. This position has responsibility for the quality, quantity, timeliness, and scientific acceptability of drug discovery activities that result in reports that are required for internal decision-making.

CONTACTS: Principal recurring contacts, including their frequency and purpose.

INTERNAL:

Moderate contact with various levels of R&D.

EXTERNAL:

Limited contact with CROs and laboratories, universities and appropriate professional groups as necessary.

WORKING ENVIRONMENT:

Domestic and international travel to scientific conferences may be required. Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

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