丹麦技术大学(DTU)2025年博士后招聘（iPSC-NK细胞治疗工程）

Postdoc in Therapeutic Engineering of iPSC-NK cells

Employer

Technical University of Denmark (DTU)

Location

Copenhagen, Hovedstaden (DK)

Salary

Competitive

Closing date

30 Mar 2025

A 2.5-year position for an experienced postdoc is available within the research group ‘Biotherapeutic Glycoengineering and Immunology’ headed by Professor Steffen Goletz and is funded by the DigitSTEM initiative. Our research group belongs to the Section of Medical Biotechnology at the Department of Biotechnology and Biomedicine.

In our research group, we apply and develop advanced next generation antibody engineering as well as cellular and molecular glycoengineering technologies to elucidate the role of glycosylation's within complex immunological networks and disease and to generate novel therapeutic approaches and drug candidates. Our main therapeutic interest is within immuno-oncology as well as infectious and lung diseases. One focus lies within cellular engineering and glycoengineering of human innate immune cells using gene editing for highly effective cell-based immunotherapeutics and the design and development of their manufacturing processes. Further focus areas are within next generation antibody engineering with bi-/ multi-specific and multimodal antibodies, phage display technologies, exosome engineering and drug delivery, gene therapy, NK- and DC- cell based therapies and their mammalian bioprocess engineering and manufacturing. We also have a strong focus on innovation and entrepreneurship.

The DigitSTEM initiative is a four-year stem cell focused research collaboration between The Technical University of Denmark (DTU), the The Novo Nordisk Foundation Center for Stem Cell Medicine (renew) at University of Copenhagen, and Bioneer A/S that aims at developing new in vitro disease models and therapeutics using human pluripotent stem cells (hPSCs).

The current position focuses on engineering, glycoengineering and differentiation of human induced-pluripotent stem cells (iPSCs) into NK-cells, inducible gene-editing, exosome-based gene editing and bridging activities to our AI- assisted manufacturing approach.

Responsibilities and qualifications

You as the postdoc will work with a team of Senior scientists, postdocs, and PhD students and in close collaboration with academic and industrial collaborators within the DigitSTEM initiative to establish a novel iPSC-derived NK-cell platform for next generation biotherapeutics.

You as the postdoc candidate for this challenging project are highly motivated and must be extensively trained and experienced with a track record in human cell engineering and gene editing, NK cell therapeutics and NK-cell biology, cellular immunology and assay technologies, in vitro 2D- and 3D cancer models, as well as immunooncology in differentiation of NK cells from human iPSCs and within NK-cell biology and assay systems. A prior postdoc in this field is advantageous. Knowledge and skills in stem cell engineering, inducible gene editing technologies, differentiation of NK-cells from iPSC, exosome based gene delivery, antibody and single-domain antibody engineering and discovery, mammalian cell manufacturing, cell-line development, and, glycoengineering, glycoanalytics, and big data analysis will be of great advantage. Moreover, you as the postdoc is expected to contribute to inter connective team tasks as well as in teaching and supervision of PhD, BSc, and MSc students.

You must hold a PhD degree in a relevant life-science discipline (cellular engineering, NK cell or stem cell biology, immunology, immunooncology or alike), have excellent communication skills and be extensively trained in immunology, stem cell biology, cellular engineering, cell culture systems, and computational data analysis.

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 2.5 years.

Starting date is 1st May 2025 (or according to mutual agreement). The position is a full-time position.

You can read more about career paths at DTU here.

Further information

Further information may be obtained from Prof. Steffen Goletz (sgoletz@dtu.dk), DTU Bioengineering.

You can read more about DTU Bioengineering at www.bioengineering.dtu.dk.

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure

Your complete online application must be submitted no later than 30 March 2025 (23:59 Danish time).

Apply at: Postdoc in Therapeutic Engineering of iPSC-NK cells

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

Application (cover letter)

CV

Academic Diplomas (MSc/PhD – in English)

List of publications

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science- and biotech industries and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people

DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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