英国杜伦大学2025年博士后招聘（二氧化碳信号与可持续性）

Postdoctoral Research Associate in Carbon Dioxide Signalling and Sustainability

Employer

Durham University

Location

Durham, United Kingdom

Salary

£38,249 - £45,413 per annum

View less categories

Faculty Jobs

Engineering & Mathematics, Chemical & Biological Engineering, Science & Technology, Life Sciences

Administrative Jobs

Academic Affairs, Research Staff & Technicians

Position Type

Postdoc

Employment Type

Full Time

Institution Type

Four-Year Institution

The Role

Carbon dioxide and sustainability

Carbon dioxide is essential for life. It is at the beginning of every life process as a substrate for photosynthesis or chemosynthesis. It is at the end of every life process as the product of aerobic respiration and post-mortem decay. As such, it is not a surprise that this gas regulates such diverse processes as cellular chemical reactions, transport, maintenance of the cellular environment, behaviour and immunity. Carbon dioxide is a strategically important research target for crop responses to environmental change, insect-borne disease and public health. However, we know very little of the direct interactions of carbon dioxide with the cell, despite the importance of the gas to biology.

Carbon dioxide mediates the earliest known example of a protein post-translational modification (PTM), identified on haemoglobin in 1928. Carbon dioxide can directly combine with select protein groups to form carbamates. Influential research programmes from the 1920s-80s demonstrated that the carbamate PTM regulates oxygen-binding in haemoglobin and activates the carbon dioxide-fixing enzyme Rubisco. George Lorimer proposed carbamate PTMs to regulate biological responses to carbon dioxide in 1983. However, the carbamate PTM is unstable outside the cell, and its identification presents significant analytical challenges. Several stable carbamates have been identified in protein molecular structures. Still, the technical difficulties in their widespread identification have resulted in carbon dioxide-mediated carbamylation being significantly understudied as a PTM.

Direct protein targets for carbon dioxide sensing are mainly unknown. We have developed technology to identify carbon dioxide-binding proteins systematically. We propose investigating a newly identified carbon dioxide binding site on Rubisco, the plant carbon dioxide-fixing enzyme. The project aims to understand how carbon dioxide regulates Rubisco function at a binding site distinct from the enzyme's active site and how this binding can be engineered to improve Rubisco's catalytic activity. The research programme will provide insight into direct molecular responses to carbon dioxide in prokaryotic and eukaryotic photosynthetic organisms. A significant outcome of this proposal will be photosynthetic organisms with enhanced yield in industrial and agricultural biotechnology. The work will be performed in collaboration with colleagues at Lancaster University.

The position offers an exciting opportunity to develop interdisciplinary biosciences and physical sciences skills. Please see here ( https://pubmed.ncbi.nlm.nih.gov/?term=cann+mj&sort=pubdate&size=200 ) for publications from the PI in this and related fields.

The post is fixed term for 36 months, and the successful candidate will be working with Prof Martin Cann (PI; Dept of Biosciences) at Durham University.

更多最新博士后招聘信息请关注博士后招聘网微信公众号（ID：boshihoujob）

祝君：学业有成，学成归来。

请您在邮件申请时在标题注明信息来自：博士后招聘网-boshihoujob.com，电话咨询时说明从博士后招聘网(www.boshihoujob.com)看到的博士后招聘信息。

声明：凡本网注明“来源：XXX”的文/图等稿件，本网转载出于传递更多信息及方便产业探讨之目的，并不意味着本站赞同其观点或证实其内容的真实性，文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜，请与我们联系。邮箱：boshihoujob@163.com。