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Dissecting mechanisms of tolerance induction in dendritic cells by genetically modified cholera toxin

Introduction

At AstraZeneca We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca’s commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines.

Your comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists.

Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers.

Accountabilities/Responsibilities

• Preparing recombinant modified cholera toxin proteins and establishing in vitro murine dendritic cell (DC) models

• Assessing the functional capacity of toxin-treated DC to promote tolerance versus immunity in T cells by marker-assisted analysis

• Performing gene expression profiling induced by cholera toxin exposure to promote tolerance or immunity

• Communicating results both within AstraZeneca and at external meetings

• Publishing findings in high-impact scientific journals

• A PhD-level education

• A strong Immunology background with hand on in vivo experience

• A strong scientific track record, as demonstrated by publications in peer-reviewed journals

• The ability to independently design and execute incisive experiments, interpret results and formulate testable hypotheses for follow-on experiments

Desirable experience

• cellular signalling

• Lab experience in recombinant proteins, cell culturing and RNA deep sequencing

• Bioinformatics knowledge with experience of working on large data sets to extract key biological information

Skills & Capabilities

• The ability to work equally well as an individual or as part of a team

• A commitment to science and outstanding communication skills

As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. What’s more, we support and encourage our people in discovering their own potential. Excellent learning and development opportunities will be available to you throughout your career here.

This position is initially a 2 year fixed term contract

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, or protected veteran status and will not be discriminated against on the basis of disability….

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