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US Postdoctoral Opportunity Pharmacology- pharmacokinetics (PBPK) modeling

Employer：AstraZeneca US

Posted：Friday, 18 April 2014

Closes：Friday, 25 April 2014

Ref:14-50098661

Location:MA, Waltham

Job Role :Clinical, Pharmacokinetics

Contract Type :Permanent

Hours :Full Time

Salary:not specified

Furthur Information

Position Title: Pediatric physiologically based pharmacokinetics (PBPK) modeling to guide clinical trial design

At AstraZeneca We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca's commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines.

Your comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists.

Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers.

 

Candidate Focus and Challenge

 

Major responsibilities:

* Perform literature searches and evaluate available clinical pediatric reports

* Collection of both preclinical and clinical adult and pediatric data for identified drugs

* Develop PBPK models and population allometric scaling models with the collected data

* Develop an approach to compare pros and cons of both methodology and propose good practice based on findings

* Validate proposed good practices with emerging data

* Develop skills in both clinical pharmacology and pharmacometrics and it's impact in drug development process especially toward pediatric development

* Willing to develop and freely share new idea to improve or enhance current process

* Actively engaged with all the AZ and academic supervisors

* Collaborate with other scientist within Astrazenca global while able to work solitarily

* Publish scientific papers describing findings from the project and especially any novel method/approaches 

 

Key deliverables: 

Delivery of modelling and data analysis methods for the collected data and proposed good practice/recommendation

 

Requirements

Candidate Knowledge, Skills and Experience

Minimum Requirements:

* A PhD in pharmacokinetics, drug metabolism, pharmacology, mathematics, biomedical engineering or relevant discipline:

 

Preferred experience

* Pharmacokinetic modelling, physiologically based pharmacokinetic (PBPK) modelling or systems biology modeling.

* Mathematical or statistical modelling with experience in modelling biological data.

* Application of specialist in tools such as SIMCYP, Phoenix, WinNonlin, Matlab, NONMEM, R,

* Understanding of DMPK and pharmacology/safety, drug delivery, pharmacokinetic, pharmacodynamic and pediatric aspects of drug discovery and development

 

Skills and Capabilities:

* Good team working and networking skills.

* Able to demonstrate the drive and energy to deliver projects.

* Demonstrate a high degree of personal credibility.

* Work collaboratively within a team and networking

* Ability to share knowledge and interpret findings

* Strong interpersonal, organizational and communication skills

* A strong scientific track record, as evidenced by published or accepted papers in peer-reviewed journals, oral and/or poster presentations at scientific meetings

* Strong commitment to science and ability to work well within a group environment

* Good communication skill as the position will require working with colleague in cross-geographic locations.

* Collaborative and interactive personality

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation

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