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Postdoctoral Scientist - Genetics

Job Description

Searching for an enthusiastic postdoctoral researcher to work on the biology of the malaria parasite, Plasmodium falciparum. Plasmodium parasites are of huge medical importance, causing ~700,000 deaths per year and millions of infections. P. falciparum parasites are a highly tractable organism which can be reared in the laboratory and placed under strong selection. This project will use a combination of flow cytometry, genome/transcriptome sequencing and experimental evolution to identify the genetic underpinnings of disease related traits of the parasite, including drug resistance, host-cell invasion and growth rate. A large component of this project will be based at new flow sorting facilities at Texas Biomedical Research Institute located in San Antonio, TX. The postdoctoral scientist will report to Dr. Ian Cheeseman.

The successful applicant will join a new lab in a vigorous infectious disease program at Texas Biomed (including work on malaria, schistosomiasis, ebola, HIV, and hepatitis C). The Genetics department at Texas Biomed provides a stimulating environment with work on statistical and quantitative genetics, metabolomics, and proteomics and has outstanding computational, sequencing and wet lab facilities. San Antonio is a vibrant, rapidly growing city with an interactive research community.

RELEVANT PUBLICATIONS
Nair S, Nkhoma SC, Serre D, Zimmerman PA, Gorena K, Daniel BJ, Nosten F, Anderson TJ, Cheeseman IH. Single-cell genomics for dissection of complex malaria infections. Genome Res 2014; Jun; 24(6):1028-38. PMCID: PMC4032849
Nkhoma SC, Nair S, Cheeseman IH, Rohr-Allegrini C, Singlam S, Nosten F, Anderson TJ: Close kinship within multiple-genotype malaria parasite infections. Proc Biol Sci 2012; 279(1738):2589-2598. PMCID: PMC3350702.
Cheeseman IH, Miller BA, Nair S, Nkhoma S, Tan A, Tan JC, Al Saai S, Phyo AP, Moo CL, Lwin KM, McGready R, Ashley E, Imwong M, Stepniewska K, Yi P, Dondorp AM, Mayxay M, Newton PN, White NJ, Nosten F, Ferdig MT, Anderson TJ. A major genome region underlying artemisinin resistance in malaria. Science 2012; Apr 6; 336 (6077):79-82. PMCID: 22491853

EDUCATION/EXPERIENCE/SKILLS: REQUIRED: Ph.D. in genetics, parasitology, molecular biology or a related discipline. The applicant should have substantial experience in flow cytometry and cell culture work, though this need not be limited to work on malaria parasites. The applicant is expected to work closely with the PI on this project, though there will be opportunities to pursue independent research project

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