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POSTDOCTORAL FELLOWSHIP available in Virology at the University of Utah – School of Medicine. NCI/NIH-funded projects focus on EBV and KSHV RNA-binding proteins involved in gene regulation and their functional interactions with cellular proteins and messenger RNAs. High throughput sequencing, recombinant molecular genetics and proteomics are being used to determine the role of virus proteins in modulating host cell gene expression.  Particular areas of interest are:

1)Modulation of host cell splicing by EBV and KSHV (See Verma, D, Bais, S, Gaillard, M and Swaminathan, S. Epstein-Barr virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicing. J. Virol. 2010, 84(22):11781-9).

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977868/

2)The role of host cell chromatin modifying proteins in regulating virus replication (Li DJ, Verma D, Mosbruger T, Swaminathan S, CTCF and Rad21 Act as Host Cell Restriction Factors for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Replication by Modulating Viral Gene Transcription. PLoS Pathog. 2014 Jan;10(1):e1003880. doi: 10.1371/journal.ppat.1003880. Epub 2014 Jan 9.

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003880

3)The mechanisms by which interferon-induced host proteins inhibit virus replication.

4)Antiviral drug discovery (Verma D, Kim EA, Swaminathan, S. Cell-based screening assay for antiviral compounds targeting the ability of herpesvirus posttranscriptional regulatory proteins to stabilize viral mRNAs. J Virol. 2013, 87(19):10742-51.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807395/

The successful applicant will be expected to contribute to planning experiments and writing manuscripts and grant applications in addition to carrying out bench research. A Ph.D or M.D. degree is required and experience in virology is desirable. An ability to work in a team environment is also important.  If interested, please send CV and names of three references by e-mail to Brittany.Bellows@hsc.utah.edu

Our laboratory is located in a newly renovated 4,000 square foot Infectious Diseases research facility in the School of Medicine Building at the University of Utah in Salt Lake City. The Department of Medicine received over $30 million in research funding and the University of Utah received more than $450 million in grants in 2010. The University of Utah was ranked first in the country along with the Massachusetts Institute of Technology (MIT) in creating new startup companies from research-based inventions.  The University of Utah consistently ranks in the top 25 in the United States for federally funded research in public universities and awards over 2,000 graduate degrees annually.

The University of Utah is an Equal Opportunity/Affirmative Action employer and educator. Minorities, women, and persons with disabilities are strongly encouraged to apply. Veterans preference. Reasonable accommodations provided.

For additional information: http://www.regulations.utah.edu/humanResources/5-106.html

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