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Postdoctoral Fellow : Columbia, MO, United States

The International Institute of Nano and Molecular Medicine (I2NM2) at the University Of Missouri – Columbia (MU) is seeking postdoctoral candidates in chemistry. I2NM2 houses state-of-the-art research facilities and instrumentation.

The research projects pursued by the I2NM2 are as diverse and eclectic as the fields of synthetic, nano and biochemistries. Specific interests of the Institute are new structures and reactions, which find applications in supramolecular chemistry, nanotechnology, molecular recognition and biomedicine. Current exploratory research emphases include:

1.Boron Neutron Capture Therapy (BNCT) of cancer
2.Target-specific multifunctional nanomolecular drug delivery systems carrying both diagnostic and therapeutic agents
3.Rotary molecular motors and their applications in biomedicine
4.Polyhedral boranes and carboranes as novel and versatile pharmaceutical building blocks

Recent articles highlighting these research areas – (1) “Boron Neutron Capture Therapy Demonstrated in Mice Bearing EMT6 Tumors Following Selective Delivery of Boron by Rationally Designed Liposomes.” Proc Natl Acad Sci U. S. A. 2013, 110, 6512; (2) “cRGD Peptide-Conjugated Icosahedral [closo-B12][2-] Core Carrying Multiple Gd[3+]-DOTA Chelates for Integrin-Targeted Tumor Imaging” Inorg Chem 2013, 52, 1701; (3) “A New Heterobifunctional Dodecaborane Scaffold for Drug Delivery Applications” J Am Chem Soc 2013, 135, 13204; (4) “Carborane-derived Local Anesthetics are Isomer Dependent” ChemMedChem 2015, 10, 62; (5) “Direct Observation of Bis(dicarbollyl)nickel Conformers in Solution by Fluorescence Spectroscopy: An Approach to Redox-Controlled Metallacarborane Molecular Motors” Inorg Chem 2014, 53, 10045.

The postdoctoral fellow will carry out exploratory research in either synthetic organic, bio-organic or organometallic chemistry with some emphasis on polyhedral boranes, carboranes, metallacarboranes and related chemistries. Knowledge of computational chemistry is a plus.

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