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ERC-funded Post-doctoral Fellow in Immunology, Cell Migration, 2-Photon-Microscopy

The Förster laboratory at Hannover Medical School, MHH, seeks to fill an open position of a Post-Doctoral Fellow.

The focus of the group is on the identification of the molecular and cellular mechanisms that control the functional organization of lymphoid organs (for some recent publications see e.g., Wendland et al Immunity 2011; Braun et al Nature Immunology; Fleige et al J. Exp.Med. 2014; Ulvmar et al Nature Immunology 2014). The Förster group has recently been awarded the prestigious ERC-advanced grant of the European Research Council (ERC).

The Project:

The continuous migration of immune cells to lymph nodes (LN) is of utmost importance for the induction of both protective immunity as well as immunological tolerance. Despite this pivotal role, little is known regarding migration paths and the molecular cues regulating homing of immune cells that arrive via afferent lymphatic vessels to LN. This conspicuous lack of knowledge is primarily due to profound technical limitations. The Förster lab recently developed a highly innovative technique of micromanipulator-guided injections into afferent lymph vessels that drain into the popliteal LN of living mice allowing precise delivery of very low numbers of cells into a LN. This approach, in combination with multicolor 2-photon in vivo microscopy, will now allow new and ground-breaking insights in routes, cellular and molecular mechanisms that regulate entry of cells reaching LNs via afferent lymphatics. Results obtained from these studies will provide fundamentally new insights in processes that regulate immune cell homing to LN and the induction of primary and recall memory immune responses. Furthermore, this information will build a broad basis for the development of novel vaccination strategies and to understand how to interfere with tumor spread to lymph nodes. Initial Funding is available for 4 years!

The Förster Lab:

is a fully equipped molecular and cellular immunology laboratory that harbors several multicolor flow cytometers, high speed cell sorters and an array of microscopes including 2-photon microscopes. The group is embedded in a multidisciplinary and highly collaborative molecular medicine research environment including state-of-the-art animal facilities.

The Institution:

In 2012, Hannover Medical School has been ranked the #1 German Medical School by the German Research Foundation (DFG, equivalent to NIH) in the category “research funding per professor”, and belongs to the top 3 lung transplantation centres worldwide. Program project grants include the cluster of excellence REBIRTH and several DFG-funded “Collaborative Research Centers, SFB). MHH offers a team-oriented environment with a structured mentoring/professional development program.

Required qualifications and terms of employment:

Interested candidates should have an outstanding background in cellular or molecular Immunology, and or 2-Photon microscopy and ideally should have received their PhD (respectively DVM/MD or equivalent degree) not later than 5 years ago. Candidates who are just about to finish their doctoral studies are also welcomed to apply. The project can be started immediately. The working language is English. Salary will be based on the candidate’s level of experience and is competitive with NIH level. Benefits are excellent

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