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Two Postdoc positions and one Doctoral student for studies of actin and myosin – fundamentals and nanotechnological applications

Location: Research group of A Månsson at the Department of Chemistry and Biomedical Sciences at the Linnaeus University, Kalmar, Sweden

1. Postdoc in studies of actin filament dynamics

The project is part of a five-year EU-Horizon2020 project, Bio4Comp, involving Linnaeus University, Lund University, Technical University of Dresden, Fraunhofer Institute Munich, Molecular Sense Ltd. Oxford and Bar-Ilan University, Ramat Gan, Israel. The overall aim is upscaling of a recently published (PNAS, 113:2591-6, 2016) proof of principle bio-nano-device for parallel computation to overcome shortcomings of conventional serial computers in solving combinatorial problems. In the device, molecular motor propelled cytoskeletal filaments (e.g. actin filaments), solve problems by traversing nanofabricated mazes of different geometry. The focus of the current subproject is modulation of actin filament dynamics with respect to polymerization-depolymerization kinetics and flexural rigidity, e.g. using actin binding proteins and genetic or chemical engineering. Related tasks will be methods for identity labelling of individual actin filaments. 

2. Doctoral student in biomedical sciences: actin-myosin studies

The project is part of a five-year EU-Horizon2020 project, Bio4Comp as described in detail under point 1 above. The focus of the PhD project is on the actin-myosin biology and the interaction of this motor system with various artificial surfaces and environments with the purpose to aid upscaling and optimization of the actin-myosin based biocomputation device. 

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