【简介】博士后招聘网整理分享“美国西北大学招收病毒学博士后”，浏览查询更多博士后招聘计划请访问博士后招聘网。

Postdoctoral Fellow : Chicago, IL, United States

Postdoctoral positions in mRNA translational control during virus infection

Postdoctoral positions are available on an NIH funded research project to study the regulation of mRNA translation during poxvirus infection under the supervision of Dr. Derek Walsh. Dr. Walsh is a newly appointed Associate Professor at the Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, located in the heart of downtown Chicago.

Recruitment of ribosomes to mRNAs is regulated by an array of eukaryotic translation initiation factors. Control of gene expression at the translational level functions in many important biological processes including rapid responses to environmental changes, developmental programs, cellular transformation, neuronal plasticity and viral infection. Indeed, no matter how self-sufficient in other processes they may be, all viruses remain absolutely dependent on gaining access to host ribosomes. This forms the crux of a host-pathogen battle to control translation factor activity that plays a central role in determining the outcome of infection. Understanding these events provides invaluable insights into the lifecycle of these pathogens and host antiviral responses, as well as basic mechanisms of translational control. Our work focuses on how translation factors regulate both host and viral mRNA translation during infection with Vaccinia Virus, a poxvirus closely related to Variola Virus, the causative agent of smallpox. Poxviruses are large double-stranded DNA viruses that replicate in the cytoplasm. Our previous work has shown that poxviruses redistribute specific host translation factors to sites of virus replication and activate upstream signaling pathways to stimulate translation factor activity, thereby facilitating viral protein synthesis and replication. Our ongoing work is focused on understanding how poxviruses accomplish this, as well as its contribution to regulating viral protein production and host responses to infection.

Candidates must have a PhD or equivalent with research experience in one or more of the following areas: virology, cell biology, fluorescence microscopy, molecular biology. Intersted applicants should submit a complete CV, a brief description of their research, and the name and contact details for three referees to derek.walsh@northwestern.edu.

Applications will be reviewed immediately until suitable candidates are identified, with start dates as early as August 2014.

请您在邮件申请时在标题注明信息来自：博士后招聘网-boshihoujob.com，电话咨询时说明从博士后招聘网(www.boshihoujob.com)看到的博士后招聘信息。

声明：凡本网注明“来源：XXX”的文/图等稿件，本网转载出于传递更多信息及方便产业探讨之目的，并不意味着本站赞同其观点或证实其内容的真实性，文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜，请与我们联系。邮箱：boshihoujob@163.com。