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MRC Post Doctoral Research Scientist 

Host-Microbe Co-Metabolism group 

Fixed-Term, 3 years

Salary £35,340 – £38,181 pa inclusive

London, UK

We have a role in the Host-Microbe Co-metabolism group headed by Dr Filipe Cabreiro. The LMS is an Institute funded by the MRC and part of the Faculty of Medicine, Imperial College. We are located on the Hammersmith Hospital Campus in West London (W12). The institute has first-class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the excellence of Imperial College. For more information, visit https://lms.mrc.ac.uk

You will join a research team that works at the intersection of organismal biology, microbiology, metabolism and systems biology. Recent questions we have tackled include:

• What are the metabolic pathways in bacteria that mediate the efficacy of fluoropyrimidine cancer therapy (Scott et al., 2017 Cell)? 

• How does the anti-diabetic drug metformin metabolically rewire E. coli to increase host lifespan (Cabreiro et al, Cell 2013). 

• How does the genetic landscape of an organism influence interventions for lifespan extension (Burnett et al, Nature 2011)?

We are positively obsessed with how the environment (e.g nutrition and drugs) alter the metabolic communication between the microbiome and the host, in the context of disease. Candidates must have a strong publication record, excellent verbal and written communication skills, and a track record of addressing scientific problems in an innovative, creative, thoughtful and systematic manner. Candidates with an experimental background should have substantive experience in molecular techniques for the genetic manipulation of prokaryotes. Candidates with a mainly metabolism/ageing background should be proficient in handling C. elegans as a model organism. Candidates keen to mix wet (E. coli or C.elegans) and dry lab computational work are particularly encouraged to apply. Whatever your background, a keen interest in metabolic or systems biology processes is a must.

Please contact Dr Cabreiro for further information (f.cabreiro@lms.mrc.ac.uk).

This is an MRC Postdoctoral Scientist position providing training and development supporting post-doctoral scientists in early or changed career paths helping establish them as successful research scientists in their chosen field. The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings.

The MRC London Institute of Medical Sciences is a research institute within UK Research and

Innovation. UK Research and Innovation is a new entity that brings together nine partners to create an

independent organisation with a strong voice for research and innovation, more information can be found

at www.ukri.org

For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/959 and upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the JD and PS). Please quote reference LMS – 858.

Applications which do not provide a cover letter will not be considered.

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