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3-year Postdoc/Assistant Professor Fellowship in GPCR crystallography and cryo-EM : Copenhagen, Denmark

The UCPH Receptor Structural Biology Group (Kastrup group) and Computational Drug Design Group (Gloriam group), Department of Drug Design and Pharmacology, University of Copenhagen wish to employ a joint Post Doc in G protein-coupled receptor (GPCR) crystallography. The position starts 1. September 2018 or soon thereafter (latest Jan 1st) and lasts for 3 years.

Groups 

Professor Jette Sandholm Kastrup, UCPH (http://drug.ku.dk/research/biostructural_research/) has a strong track record of producing receptor crystal structures (~100 receptor structures deposited in the Protein Data Bank). She has a strong international network with leading medicinal chemists and pharmacologists.

The Gloriam group (www.gloriamgroup.org) conducts computational drug design, tightly integrated with leading chemists and pharmacologists, and structure-function studies of G protein-coupled receptors (GPCRs) – one of the largest drug target families. The group has in the last two years published in e.g. Nature, Cell, Nature Reviews in Drug Discovery, Nature Chemistry and Nucleic Acids Research.

Project 

This Post Doc fellowships is one of five that will take part in an ambitious interdisciplinary project spanning chemistry, pharmacology, structural biology, computational drug design and scientific database development. It is supported by the Novo Nordisk Foundation (Hallas-Møller Ascending Investigator) and headed by David Gloriam. The project focuses on GPCR biased signalling to illuminate the pathways to function and disease.

The overall objective of the project is to establish a joint public platform to consolidate the GPCR signalling field, and to identify novel mechanisms and ligands of biological and therapeutic relevance. The Post Doc within crystallography/cryo-EM will focus on (preferably biased) agonist complexes with the Free Fatty Acid 4 (FFA4) receptor, as well as other receptors for which structures are known but none with biased agonists. GPCR crystallisation requires comprehensive construct engineering to achieve optimal protein stability, expression in both insect and mammalian cells, homogeneity and crystal packing. The quality of the constructs will be evaluated based on the receptor yield and aggregate/monomer ratio (size-exclusion chromatography), as well as the thermostability (thermoshift assay). Crystallisation trials will benefit from our new state-of-the-art Crystal Gryphon LCP robot capable of efficiently screening numerous construct-condition combinations. Cryo-EM studies will take advantage of new state-of-the-art core facilities in Denmark.

Qualification requirements 

Mandatory requirements 

• A PhD degree within structural biology 

• Solid experience with expression and purification of membrane proteins 

• Demonstrated ability to independently learn new concepts and solve biological problems 

• Excellent communication skills: fluency in English and experience in writing scientific texts

Additional meriting qualifications 

Experience of, and skills in: 

• G protein-coupled receptors 

• Protein crystallography/cryo-EM 

• Analysis of molecular structures and interactions 

• Experience with crystallographic software packages

General job description 

Your key tasks as a Post Doctorial fellow at the Faculty are to: 

• Manage and carry through your research project 

• Write scientific articles 

• Participate in the education and guidance of students

Additional requirements to be hired as an assistant professor 

To be hired in the assistant professor the applicant should already have done a postdoc, supervised PhD students and have additional qualifications to document progression towards a competitive career (high-impact publications, own grants etc.). Employment as assistant professor includes teaching obligations and the possibility to upgrade pedagogical qualifications.

Key criteria for the assessment of applicants 

• Professional qualifications relevant to the project 

• Relevant work experience 

• Publications 

• Other professional activities 

• Language skills 

• Good interpersonal skills

Terms of employment 

The post will be filled according to the Agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The post is covered by the Protocol on Job Structure.

Questions 

For further information about the post, please contact Professor Jette Sandholm Kastrup via jsk@sund.ku.dk or David Gloriam via david.gloriam@sund.ku.dk.

Application 

The application, in English, must be submitted in the online application form. The application must include the following appendices: 

Appendix 1: curriculum vitae with documentation of education. 

Appendix 2: a complete list of publications. 

Appendix 3: documentation of additional research qualifications, incl. letter of recommendations.

In addition to the material the applicant wishes to be included in the assessment, the Assessment Committee may include further material in their assessment of the applicant, such as reference letters. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee. No research/project plan needs to be submitted. Following processing of the application, any application material sent will be destroyed.

The applicant will be assessed according to the Ministry of Science Technology and Innovation Executive Order no 284 of 25. April 2008.

University of Copenhagen and Denmark 

Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 39,000 students and 10,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more at www.sund.ku.dk and www.drug.ku.dk.

Copenhagen is a modern capital with plenty of opportunities in culture, design, architecture, restaurants and a diverse nightlife. At the same time, the city offers beaches, beautiful parks and green nature areas, and the Copenhageners bike everywhere. The Danish society prioritises a good work-life balance, and the work culture is well adjusted for families with children. Read more at http://ism.ku.dk/.

Deadline: 15 August 2018 

Employer: University of Copenhagen

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career. 

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