【简介】博士后招聘网整理分享“美国国立卫生研究院2020年博士后职位招聘（运用X射线晶体学、核磁共振和电子显微镜研究中心）”，浏览查询更多博士后招聘计划请访问博士后招聘网。

美国国立卫生研究院2020年博士后职位招聘（运用X射线晶体学、核磁共振和电子显微镜研究中心）

Postdoc fellowship to study centrosomes using X-ray crystallography, NMR, and electron microscopy

Employer

National Institutes of Health

Location

Bethesda, Maryland, and Washington D.C. area

Salary

Starts at $55,700 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance

Posted

February 12 2020

Ref

Postdoctoral fellowship

Discipline

Life Sciences, Biochemistry, Structural Biology

Position Type

Full Time

Organization Type

Academia

Job Type

Postdoc Fellowship

Investigating the architecture and function of nanoscale centrosomal self-assemblies using X-ray crystallography, NMR, biochemistry, and electron microscopy

Position Description: The architecture of a cell is established through varying degrees of hierarchical organizations from single molecules to macromolecular assemblies. Investigating how these molecules interact with one another to form a higher-order structural entity with a new biological function is a key step to unlocking the mystery of life. We are mainly interested in understanding the molecular bases of how the physicochemical properties of pericentriolar scaffold proteins drive the formation of micron-scale self-assemblies with distinct cellular functions. Recently, we found that human polo-like kinase 4, a key regulator of centriole duplication, forms a high M.W. complex with centrosomal scaffold proteins, which cooperatively self-assemble into a higher-order architecture around a centriole in a concentration-dependent manner. Notably, a failure in these events can result in abnormal centrosome numbers, improper spindle formation, and chromosome missegregation that ultimately lead to the development of various human diseases, including cancer, ciliopathy, and microcephaly. Thus, we aim to elucidate the molecular mechanism underlying the assembly of pericentriolar architectures to ultimately understand the etiology of centrosome-associated human diseases.

Fellows who have an expertise in structural biology (X-ray or NMR) and/or electron microscopy with a keen interest in investigating the structure and function of nanoscale centrosomal self-assemblies are encouraged to apply.

Applicants should have a Ph.D. (or expected) or M.D. equivalent at the time of joining the lab. For more information, please click the link below.

https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee

To apply, please send CV and three names of references to Dr. Kyung Lee (kyunglee@mail.nih.gov).

Salary starts at $55,700 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance

Employer Name: National Cancer Institute, NIH.

Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U. S. A.

Selected publications:

1. Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Park JE, et al. Nat Commun. 10(1):4959, 2019.

2. Molecular architecture of a cylindrical self-assembly at human centrosomes. Kim TS, et al. Nat Commun. 10(1): 1151, 2019.

3. Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Park SY, et al. Nat. Struct. Mol. Biol. 21(8): 696-703, 2014

The NIH is dedicated to building a diverse community in its training programs.

请您在邮件申请时在标题注明信息来自：博士后招聘网-boshihoujob.com，电话咨询时说明从博士后招聘网(www.boshihoujob.com)看到的博士后招聘信息。

声明：凡本网注明“来源：XXX”的文/图等稿件，本网转载出于传递更多信息及方便产业探讨之目的，并不意味着本站赞同其观点或证实其内容的真实性，文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜，请与我们联系。邮箱：boshihoujob@163.com。