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Postdoc position in cell-migration and systems-scale drug discovery

Employer BRIC - Biotech Research & Innovation Centre, University of Copenhagen

Posted Friday, September 12, 2014

Location Denmark

Discipline Life Sciences, Biochemistry, Biology, Molecular Biology

Position Type Full Time

Further information

Our group and research

The Linding Laboratory is a network biology research group based at the Biotech Research and Innovation Centre, University of Copenhagen (BRIC). Our lab explores biological systems by both generating high-throughput data and developing algorithms aimed at predicting cell behavior with accuracy similar to those of weather or aircraft models. A major focus of our lab is studying cellular signal processing and decision-making during cancer progression.

Symphogen A/S (www.symphogen.com) is a privately held biotech company based in Ballerup, close to Copenhagen, Denmark. Symphogen´s proprietary technology offers a method for the production of unlimited amounts of highly purified, antigen-specific, recombinant antibody mixtures - a new class of therapeutic anti-bodies with a number of prominent advantages compared to existing monoclonal antibody or immunoglobulin therapies. This new antibody technology has a significant market potential and the company has developed a broad pipeline with two products in clinical development and several preclinical programs.

The research project

In this position, the successful applicant will perform large-scale integrative studies, combining next generation sequencing, global phospho-proteomics and high content screening, with computational models in order to identify the signaling networks involved in cell migration. Following target identification the applicant will generate novel antibody based anti-cancer therapies that can be taken further into pre-clinical and clinical testing.

The identified targets and therapies will be utilized in a network medicine project focused on developing novel treatments for cancer and will be related to our recent studies on phosphorylation networks and network medicine (Creixell et al. 2012 Nature Biotechnology, Erler & Linding Cell 2012, Bakal, Linding et al. Science 2008, Tan et al. Science 2009 and Tan et al. Science 2011 and Jørgensen et al. Science 2009). The project is a collaboration between the Linding Laboratory, Prof. Doug Lauffenburger's lab at MIT, Prof. Norbert Perrimon's lab at Harvard, Assoc. Prof. Janine Erler's lab at BRIC, Symphogen A/S, Silicon Graphics Inc. and PerkinElmer GmbH.

Start: As soon as possible.

Duration: 3 years 

Place of employment

The successful applicant would be employed at BRIC, University of Copenhagen. However the laboratory is physically based on the Technical University of Denmark's campus in Lyngby. Time will be shared between the Linding Laboratory and Symphogen A/S as required by the project.

Application

Your application must be submitted via the university's job portal on http://employment.ku.dk/faculty/. Follow the link for further details regarding application procedure.

Application deadline: 5th October 2014

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