首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

一、实验室介绍

Yun实验室团队以蝾螈为模型系统，致力于揭示器官再生的细胞与分子机制，解析演化差异对再生潜能的影响，并探索再生与衰老的深层关联。我们采用两种具有基因操作可行性的蝾螈模型——墨西哥钝口螈（美西螈，Ambystoma mexicanum）和西班牙肋突螈（Pleurodeles waltl），这两种生物以极强的再生能力和几乎可以忽略的衰老特征而著称。通过整合前沿遗传学技术、细胞分子生物学方法、先进成像系统、多组学分析与跨物种比较研究，我们致力于揭示再生与衰老的基本规律，推动基础研究与治疗应用。

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我们提供国际化、创新性强且以科学为导向的科研环境。入选者将加入我们覆盖德国、英国、美国的国际合作网络，并有机会直接参与国际项目。实验室隶属于新成立的首都医学科学创新中心的再生生物学与医学研究所。

二、岗位信息

01、实验室管理员

我们正在为新建实验室招募一名技术娴熟的科研管理人员。

1）岗位职责

1.设备、试剂及实验室耗材的采购与管理；

2.库存维护与档案记录；

3.常规设备维护及实验室日常运营；

4.新成员实验技术与设备操作培训；

5.协助动物实验伦理审批及许可证办理；

6.开展基础分子/细胞生物学实验、图像采集与数据分析；

7.参与合作研究并独立承担课题。

2）任职要求

1.分子生物学、生物化学或相关专业学位；

2.具备实验室管理经验；

3.熟练掌握以下分子生物学技术：

▸基因克隆与编辑

▸细胞培养

▸显微成像技术（共聚焦/立体荧光/光片显微镜等）

▸组织处理（样本制备、切片及染色技术，包括免疫组化IHC/IF、常规/HCR原位杂交）

4.有动物实验与转基因操作经验者优先；

5.素质要求：

▸卓越的组织协调能力

▸对细节的高度关注

▸流利的英语口语与书面表达能力

02、分子生物学技术员

我们诚聘一名熟练掌握分子生物学技术的专业人员，共同探索再生与衰老的关联机制。该职位需具备独立开展研究及团队协作能力。

1）岗位职责

运用前沿分子生物学技术开展相关研究。

2）任职要求

1.扎实的分子生物学技术背景，包括：

▸先进基因编辑技术（如CRISPR/Cas-9系统）

▸克隆技术

▸mTol2或类似转基因系统操作

▸动物转基因技术

▸细胞培养

▸组织处理技术（样本制备、切片及染色，包括免疫组化IHC/IF和常规/HCR原位杂交）

2.有再生模型研究或动物手术经验者优先；

3.素质要求：

▸细致严谨的工作态度

▸流利的英语听说读写能力

03、生物信息分析师

我们诚聘一名积极主动的生物信息学专业人员，共同探索再生与衰老的关联机制。

1）岗位职责

1.设计并开展单细胞及群体水平的生物信息学分析，包括：

▸转录组、表观遗传组（如DNA甲基化芯片、基因组数据）及蛋白质组数据分析

▸基于10XMultiome工作流程和Illumina测序平台生成的mRNA测序数据分析

2.开展跨物种单细胞分析；

3.解析空间转录组数据；

4.参与科学假说提出、实验设计、分析流程文档编写、研究汇报及论文撰写；

5.为团队成员提供技术培训与指导；

6.协调独立工作与团队协作。

2）任职要求

1.生物信息学或相关领域学位；

2.扎实的生物信息学理论基础及实践经验，尤其擅长：

▸单细胞数据分析

▸空间转录组学分析

3.必备流利的英语听说读写能力；

4.有再生生物学、衰老研究或进化生物学经验者优先。

04、博士后

我们诚邀优秀且富有科研热情的博士后研究人员加入，共同探索再生与衰老的分子关联机制。

1）任职要求

1.已获得或即将获得生物学、生物化学、计算生物学等相关专业博士学位；

2.具备突出的学术成果记录；

3.流利的英语听说读写能力；

4.具有再生生物学、衰老研究、发育生物学或进化生物学背景者优先；

5.具备以下技术经验者尤佳（满足部分即可）：

▸动物实验操作

▸组织培养技术

▸生物信息学分析

▸细胞与分子生物学实验技术

三、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

四、申请方法

请将简历、研究兴趣、3名推荐人的姓名和联系方式以及其他证明研究能力的材料发送至max.yun@cimrbj.ac.cn，并在邮件主题中注明申请人的姓名和具体职位+博士后招聘网。

联系人：Max H.Yun

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

ABOUT YUN LAB

The Yun group leverages salamander systems in order to unveil the cellular and molecular mechanisms underlying organ regeneration, determine how phylogenetic changes affect regenerative potential, and probe the links between regeneration and ageing.We employ two genetically-tractable salamander models, the axolotl (Ambystoma mexicanum) and the Iberian ribbed newt (Pleurodeles waltl), known for their extreme regenerative abilities and negligible senescence traits.Combining state-of-the-art genetics, cell and molecular biology approaches, advanced imaging, multiomics and cross-species comparative studies, we aim to uncover fundamental principles of regeneration and ageing towards basic and therapeutic applications.Further information can be found at

We offer an international, creative, science-driven and inspiring environment.The successful candidates will benefit from our large network of collaborations (Germany, UK, USA) and have immediate opportunities to contribute to international projects.Our lab is located at the newly built Institute for Regenerative Biology and Medicine, Chinese Institutes for Medical Research.

Open Positions

Lab Manager

We are seeking a skilled scientist to manage our newly established laboratory.

Main Responsibilities

a.Order equipment, reagents and lab consumables.

b.Maintain lab stocks and records.

c.Maintain general lab equipment and organisation.

d.Train new staff on common lab techniques and equipment.

e.Assist with animal protocols and licenses.

f.Perform basic molecular/cell biology, image acquisition and data analysis.

g.Conduct research collaboratively as well as independently.

Qualifications

Candidates will have a degree in Molecular Biology, Biochemistry or related subject, experience with general lab management and a strong background on molecular biology approaches including cloning, gene editing, cell culture, microscopy (e.g.confocal, stereo-fluorescence and/or light sheet), tissue processing including preparation, sectioning and staining techniques (e.g.immunostainings IHC/IF and standard/HCR in situ hybridization).Experience in animal research and transgenesis is desirable.Soft skills include outstanding organisational skills, keen attention to details and fluency in spoken and written English.

Molecular Biology Technician

We are seeking a highly skilled Molecular Biologist to join our efforts to unravelling the links between regeneration and ageing.He/she will conduct research collaboratively as well as independently.

Qualifications

The successful candidate will have a strong background on molecular biology approaches including state-of-the-art gene editing, cloning methods, CRISPR/Cas-9 technologies, mTol2 or equivalent systems, animal transgenesis, cell culture, tissue processing including preparation, sectioning and staining techniques (immunostainings IHC/IF and standard/HCR in situ hybridization).Prior experience with regeneration models and/or surgical procedures is a bonus.Soft skills include keen attention to details and fluency in spoken and written English.

Bioinformatician

We are seeking a highly motivated bioinformatician to join our efforts to unravelling the links between regeneration and ageing.

Main Responsibilities

a.Design and conduct bioinformatic analyses of data at single cell and bulk level, including transcriptomic, epigenetic (e.g.DNAm arrays, genomic data) and proteomic datasets, including mRNA sequencing data generated via the 10XMultiome workflow and Illumina sequencing.

b.Conduct cross-species single cell analyses.

c.Analyse and interpret spatial transcriptomics.

d.Contribute to hypothesis generation, experimental design, analytical pipeline documentation, research presentations and manuscript preparation.

e.Provide training/guidance to other team members.

f.Balance independent work and team collaboration.

Qualifications

Candidates should have a degree in bioinformatics or a related field, strong theoretical knowledge and experience in bioinformatics, particularly single cell data and spatial transcriptomics analyses.Fluency in spoken and written English is required.Prior experience in the fields of Regeneration, Aging or Evolutionary biology is a bonus.

Postdoctoral Researcher

We are seeking outstanding, highly motivated postdoctoral researchers to join our efforts to unravelling the links between regeneration and ageing.

Qualifications

Candidates should have a Ph.D.degree in Biology, Biochemistry, Computational Biology or related, an outstanding academic track record, and fluency in spoken and written English.A strong background and research experience in Regenerative, Ageing, Developmental or Evolutionary Biology is desirable.Ideally, candidates would be trained in animal experimentation (not exclusive), tissue culture, bioinformatics and cell/molecular biology techniques.

Welfare Treatment

a.Competitive salary based on the job applicant's work experience and abilities (salary negotiable).

b.Social insurance, paid annual leave, physical examination and supplementary medical insurance, etc.

c.Opportunities for career development and available professional guidance.

How to apply

Please send a resume, a brief summary of research interests & key accomplishments, the names and contacts of 3 referees and other materials demonstrating research capabilities to max.yun@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.

Contact person: Max H.Yun

This recruitment is valid for the long term until a suitable candidate is recruited.

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原文出处：

https://mp.weixin.qq.com/s/vdRE-eK_pymK5sW3I3Q_Ug

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