首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

一、实验室介绍

张翼研究员在北京大学获得学士和博士学位，已加入首都医学科学创新中心（CIMR）创建独立实验室。张翼实验室的主要研究兴趣是开发新型计算和实验方法，从静态、离散的样本中准确重建出动态、连续的生物学过程的历史轨迹，以便更好地理解发育、衰老、疾病发生发展的分子机制，为重大疾病的诊断和治疗提供理论依据与技术支撑。

本实验室的工作特点为干湿结合、学科交叉。欢迎不同背景的研究同事加入团队。

二维码（请点击链接查看详情）_扫码了解更多

二、实验室研究方向

实验室将综合利用深度学习、生物信息学、分子生物学、细胞生物学、动物模型、单分子测序、单细胞测序等技术和手段，开展（不限）以下课题研究：

1.开发前沿计算工具，即新型计算生物学方法，用于解析复杂数据中隐含的动态特征信息。

2.开发新型单细胞、单分子水平的实验和计算方法，从静态样本中重建生物过程的动态历史，鉴定其中关键的分子事件。

3.综合运用正向遗传学筛选、反向遗传学操作、单分子测序、单细胞多组学分析手段，解析表观基因组复制的分子机制，特别是在衰老、疾病中表观遗传信息复制的分子机制。

三、主要成果与贡献

1.开发从单细胞ATAC数据中计算细胞分裂年龄的方法 (Nat.Biotech., 2024)

2.发现DNA二级结构影响表观基因组复制 (BioRxiv, 2024)

3.开发将神经活动转化为遗传可操作对象的方法 (J.Neurogenetics, 2012)

代表性文章

Nature Biotechnology, 2024.PMID: 38724668.

Advanced Science, 2024, 11: e2308438.PMID: 38582099.

Genome Biology, 2024, 25:117.PMID: 38715110.

Neuro-Oncology, 2022, 24: 903-913.PMID: 34918118.

Journal of Neurogenetics, 2012, 26: 89-102.PMID: 22236090.

四、岗位信息

01、科研助理

1）岗位职责

1.独立或协助团队开展课题研究；

2.协助实验室运行管理。

2）任职要求

1.大学本科学历及以上，生物学、生物信息学、演化生物学及其它相关专业；

2.掌握分子生物学操作及原理，有二代测序、三代测序、细胞生物学、模式动物等研究经历优先；

3.具备良好的沟通能力和团队协作能力；

4.具备良好的英语读写和日常交流能力。

02、博士后

1）岗位职责

1.以科学研究工作为主，在PI指导下独立开展研究工作，按计划完成博士后研究任务；

2.与合作导师共同承担科研课题，发表高水平研究论文，申请各类科研项目、专利，协助指导研究生工作。

2）任职要求

1.具有生命科学、生物信息学、计算机科学、物理学或其他相关领域的研究背景，在国内外已获得或即将获得博士学位（原则上不超过3年），有物理、数学、计算机、生物信息学训练背景或三代测序、单细胞测序、Perturb-seq实验背景者优先考虑；

2.以第一作者身份在领域内主流期刊上发表过或即将发表研究论文（在BioRxiv上已公开），能够独立开展研究工作；

3.具备独立开展科研工作和指导研究生能力，具有严格的学术道德、高涨的科研热情、严谨的科研态度、良好的沟通能力和团队合作精神，具有诚实健康、乐观坚强、有上进心、勤劳刻苦的个人品质；

4.具有高效的信息检索、英语文献阅读、论文撰写能力，具备应有的分子生物学或生物信息学基本技能，熟知技术背后原理。

五、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

六、申请方法

应聘者请将个人简历、研究兴趣或计划，以及2-3名推荐人（仅限博士后应聘）的姓名及联系方式，以及其他能证明科研能力的相关电子文件发送到邮箱 zhangyi@cimrbj.ac.cn，邮件主题请注明“应聘者名字+具体应聘职位+博士后招聘网”。

联系人：张老师

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

另外本实验室欢迎有对生物信息学感兴趣的各阶段实习生、联培生前来学习交流。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The Zhang laboratory develop novel computational and experimental methods to track human development, aging, and disease across time domains on single-cell, single-molecule resolution.

The laboratory conducts cross-disciplinary research with a combination of computational and experimental biological methods.We welcome colleagues with background in physics, computer science, biology, bioinformatics, and medicine to join our team.

Lab website:QR code→（请点击链接查看详情）

Major Research Projects

The laboratory uses a combination of deep learning, bioinformatics, forward and reverse genetics, and sequencing approaches on human samples and animal models, to:

a.Develop methods to extract latent information from biological data.

b.Develop novel methods to resolve dynamic biological process from static samples.

c.Dissect the molecular mechanism of epigenome replication, particularly in aging and disease.

Major Contributions

a.Developed method to decode cell replicational age from single-cell ATAC-seq data (Nat.Biotech., 2024)

b.Provided evidence for how DNA secondary structure affect epigenome replication (BioRxiv, 2024)

c.Developed tools to convert Drosophila neuronal activity into genetic manipulable object (J.Neurogenetics, 2012)

Representative Publications

Nature Biotechnology, 2024.PMID: 38724668.

Advanced Science, 2024, 11: e2308438.PMID: 38582099.

Genome Biology, 2024, 25:117.PMID: 38715110.

Neuro-Oncology, 2022, 24: 903-913.PMID: 34918118.

Journal of Neurogenetics, 2012, 26: 89-102.PMID: 22236090.

Open Positions

Research Assistant

Main Responsibilities

a.Conducting research projects either independently or in a team.

b.Assisting PI in lab routine management.

Qualifications

a.B.S.or higher degree in biology, bioinformatics, evolutionary biology or other relevant majors is required.

b.Research experience in bioinformatics, next-generation sequencing, single-molecule sequencing (Nanopore or PacBio), cell biology and/or model animal works is preferred.

c.Self-motivated researcher with good communication skill and teamwork ability.

d.Proficient in English reading, writing, and daily communication.Passed CET 6.

Postdoctoral Researcher

Main Responsibilities

a.Conducting research projects independently.

b.Assisting PI to mentor graduate students, and write grant proposals and manuscripts.

Qualifications

a.Backgrounds in computer science, physics, bioinformatics, biology or biomedical engineering.Either about obtaining a Ph.D.or recently obtaining a Ph.D.degree (ideally within the last 3 years).

b.Have first author paper(s) published in (or accepted by) reputable journals in the field.

c.Have the ability to independently carry out scientific research and guide graduate students, have scientific research enthusiasm and rigorous scientific research attitude.

d.Learns quickly.

e.Strong research experience in either:

(i) Perturb-seq, single-cell sequencing, single-molecule sequencing, epigenomics.

(ii) Bioinformatics, deep learning, algorithm development.

f.Proficient in English reading, writing, and daily communication.

Compensation and Benefits

a.Competitive salary based on the applicant’s work experience and ability (salary negotiable).

b.Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c.Opportunities for career development and available professional guidance.

How to apply

To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zhangyi@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.

Contact person: Yi Zhang

This recruitment is valid for the long term until a suitable candidate is recruited.

Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in cellular immunotherapy to come and exchange ideas.

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原文出处：

https://mp.weixin.qq.com/s/mBLZLfaP2pCEyeM7igwmmA

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